Odowell is a professional L-Menthol manufacturers and L-Menthol suppliers in China . Odowell is ploughing in Flavors & Fragrances industry since 2012, constantly R&D new raw materials and new technology to fulfill perfumers and flavorists’ growing pursuit of product variety and quality. Our L-Menthol cas 2216-51-5 have a good price advantage, premium quality with Solid appearance, production capacity of 150 tons per year and popular in European and American markets.
L-Menthol is one of the most important flavoring chemicals. L-Menthol is widely used in medicines, cosmetics, toothpaste, chewing gum and other hygiene products, as well as in cigarettes. L-Menthol has local anesthetic and anti-irritant properties and is widely used in flavor enhancers and medicines to relieve itching, pain, and nasal congestion. When people inhale, ingest or apply menthol to the skin, menthol triggers the cold-sensing nerve (TRPM8 Receptor) on the skin to produce a cool feeling. Inhaling menthol will bring a unique cool feeling inside the biological body by stimulating the trigeminal nerve of the olfactory epithelium. L-Menthol is used in oral care as an antimicrobial, effective against streptococci and lactic acid bacteria. The maximum concentration of menthol allowed by the FDA in over-the-counter medications is 16%. Sometimes the concentration of calcium has an effect on the cold and heat receptors, mainly reflected in the difference in temperature perception. Sometimes people feel a warming sensation when they inject the calcium solution. This is because calcium will significantly increase the release frequency of heat sensation and inhibit the release of cold sensation nerves.
L-Menthol is a kind of monoterpenoid organic matter, which can produce cool feeling and bring mint fragrance. Before World War II, menthol was only obtained from plants, and the largest producers were China and Japan. During World War II, Brazil became the largest producer and supplier of menthol due to the disruption of the original trade routes. Currently, India is the largest mint grower. According to statistics, in 2007, the world's annual output of mint was about 40,000 tons. Among them, about 28% of menthol is used for oral hygiene care, 26.6% of menthol is used in medicines, 25.3% of menthol is added in tobacco products, and 11% of menthol is added in candies and desserts. Nine percent menthol is used in shaving creams and a variety of other products.
L-Menthol Cas 2216-51-5
L-Menthol is also called Natural Menthol Crystal.This substance can be extracted and refined from natural plant peppermint by steam distillation, and can also be prepared by synthetic method. At normal temperature, menthol is a colorless transparent prismatic or needle-like crystal substance. L-Menthol is an oil-soluble substance. Like other organic substances, menthol is metabolized to form glucuronide compounds, which become more water-soluble and can be easily excreted in urine.
Premium quality L-Menthol with Clear colorless liquid appearance, Odowell L-Menthol with high quality in stock and free Sample for testing. Production capacity: 150 Tons annually manufacturing for European countries and American market.
L-Menthol (Specification)
Product Name |
L-Menthol |
Synonyms |
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol;(1r,3r,4s)-(-)-mentho;(1R,3R,4S)-(-)-MENTHOL;(R)-(-)-Menthol;Emtricitabine Impurity 31;Natural Menthol Crystal;L-Meng alcohol Natural menthol Menthol (L);DL-Menthol menthol crystal extract |
CAS |
2216-51-5 |
MF |
C10H20O |
MW |
156.27 |
EINECS |
218-690-9 |
Product Categories: |
Inhibitors;Organics;chiral;Biochemistry;Terpenes;API;Terpenes (Others);for Resolution of Acids;Monocyclic Monoterpenes;Optical Resolution;Synthetic Organic Chemistry;2216-51-5 |
Mol File |
2216-51-5.mol |
L-Menthol Feature And Application
L-Menthol and its related cooling agents are widely used in the fields of food, medicine and cosmetics. Menthol was originally considered as a flavor enhancer and brings aroma, but also improves the taste of medicines, candies and the like.
1. Menthol has a wide range of applications in the pharmaceutical field, such as used as a raw material in Lianhua Qingwen Capsules, and menthol can also be used in over-the-counter products such as lip balms and cough medicines to relieve mild symptoms of dry throat and Mouth inflammation, also used in antipruritics to regulate itching.The application of peppermint in antipruritics is as follows: compound chloramphenicol liniment, children's prickly heat powder, children's prickly heat lotion, used in anti-inflammatory and anti-bacterial preparations (compound sodium borate salicylate cream, anti-inflammatory ointment), diluent and aromatic flavoring agent (peppermint water), mint drops for nasal .
2. Food field: Menthol has a wide range of applications in the food field, such as beverages, pastries, herbal tea, chewing gum, candy, frozen food, snacks, etc., are added with mint cooling products, which have a refreshing and full sensory effect.
3. Daily Chemicals: Used in oral cleaning products such as mouthwash and toothpaste to treat bad breath: compound zinc salicylate mouthwash, deodorant refreshing liquid
4. Fragrance field: Used in perfumes to enhance the effect of floral and fruity aromas. At the same time, it is also used in various essences to play a cooling effect and prepare mint essence.
5. Tobacco field: It is used as a tobacco additive to provide aroma to tobacco, reduce throat and sinus irritation when smoking, and increase the density of nicotine receptors. It is added in some traditional cigarettes and electronic cigarettes.
In addition, menthol is also used in cosmetic products such as hair conditioner, shampoo, and shampoo, and is also formulated with other skin care products for the treatment of sunburn (due to the cooling effect, it can relieve pain).
L-Menthol Details
Chemical Properties
Melting point |
41-45 °C (lit.) |
Alpha |
-51 º (589nm, c=10, EtOH) |
Boiling point |
212 °C (lit.) |
Density |
0.89 g/mL at 25 °C (lit.) |
Vapor pressure |
0.8 mm Hg ( 20 °C) |
FEMA |
2665 | MENTHOL RACEMIC |
Refractive index |
1.46 |
Fp |
200 °F |
Storage temp. |
Store below +30°C. |
Solubility |
490mg/l |
Form |
Crystals or Crystalline Needles |
pka |
15.30±0.60(Predicted) |
Odor |
at 10.00 % in dipropylene glycol. peppermint cooling mentholic minty |
Optical activity |
[α]22/D 49°, c = 10 in 95% ethanol |
Merck |
14,5837 |
BRN |
1902293 |
LogP |
3.15 at 25℃ |
CAS DataBase Reference |
2216-51-5(CAS DataBase Reference) |
NIST Chemistry Reference |
Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1«alpha»,2«beta»,5«alpha»)]-(2216-51-5) |
EPA Substance Registry System |
Levomenthol (2216-51-5) |
Safety Information
Hazard Codes |
Xi |
Risk Statements |
37/38-41-36/37/38 |
Safety Statements |
26-39-37/39-36 |
WGK Germany |
2 |
RTECS |
OT0700000 |
TSCA |
Yes |
Hazardous Substances Data |
2216-51-5(Hazardous Substances Data) |
HS Code |
HS Code |
Toxicity |
LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg |
Quality Certificates
Our company meet the highest quality requirements as stipulated in ISO9001.